Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells - PubMed
5 hours ago
- #melatonin
- #SIRT1
- #pyroptosis
- Melatonin reduces LPS-induced pyroptosis in alveolar epithelial cells.
- Melatonin downregulates ETS1 expression, which binds to the NLRP3 promoter.
- Melatonin upregulates SIRT1, leading to ETS1 deacetylation.
- SIRT1 knockdown abolishes melatonin's protective effect against pyroptosis.
- Melatonin's effects are mediated via the MT2/SIRT1/ETS1/NLRP3 pathway.