ATG5 in DCs attenuates anti-malarial cellular immune responses through interfering with TLR2-mediated CD209A/DC-SIGN expression - PubMed
4 hours ago
- #immune response
- #malaria
- #dendritic cells
- ATG5 deficiency in dendritic cells (DCs) suppresses malaria blood-stage parasite growth independently of autophagy pathways.
- Enhanced parasite-specific CD4+ T cell responses in atg5Itgax/Cd11c-Cre+ mice support activation of Plasmodium-specific CD8+ T cells.
- Increased expression of phagocytic receptor CD209A/DC-SIGN on conventional DCs due to ATG5 deficiency boosts CD4+ T cell activation.
- TLR2 signaling pathway mediates CD209A expression, which is augmented without ATG5.
- ATG5 modulates anti-malarial cellular immune responses by influencing TLR2-mediated CD209A expression in DCs, offering insights for malaria vaccine design.