Airway microbiome diversity, intra-mucosal bacteria, and spatial immunity in asthmatics and controls - PubMed
6 hours ago
- #immunity
- #asthma
- #microbiome
- Asthma is linked to reduced microbial diversity and disrupted airway mucosa.
- Study used bronchoscopy on 65 asthmatics and 44 controls to analyze bacterial OTUs via 16S rRNA.
- Bacterial foci were found in epithelium, basement membrane, and stroma via in situ hybridization.
- Clinical asthma predicted by basement membrane abnormalities, endobronchial bacterial diversity, and eosinophil counts.
- Intra-mucosal bacteria counts negatively correlated with immunity networks for antigen-specific responses and neutrophil functions.
- Basement membrane abnormalities positively correlated with adaptive immunity module.
- Eosinophil counts linked to epithelial bacterial counts and senescence pathways.
- Asthma associated with upregulation of a Treg cell network, indicating complex mucosal immune events.