Monocyte-Derived Alveolar Macrophages in ALI/ARDS: The Core Drivers of Inflammation - PubMed
5 hours ago
- #inflammation
- #macrophages
- #ALI/ARDS
- Monocyte-derived alveolar macrophages (Mo-AMs) are central mediators of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS).
- Mo-AMs originate from hematopoietic stem cells (HSCs) in the bone marrow and migrate to the inflamed lung via the CCR2/CCL2 pathway.
- Mo-AMs contribute to ALI/ARDS pathogenesis by generating cytokine storms, depleting tissue-resident alveolar macrophages (TR-AMs), disrupting the alveolar-capillary barrier, and promoting fibrosis.
- Therapeutic strategies targeting Mo-AMs include inhibiting their recruitment, inducing apoptosis, and reprogramming their proinflammatory functions.
- Mo-AMs are a promising therapeutic target for developing novel treatments for ALI/ARDS.