Differential DNA-methylation of synaptic genes in CSF and blood in schizophrenia - PubMed
10 hours ago
- #DNA-methylation
- #synaptic genes
- #schizophrenia
- Study investigates DNA-methylation patterns of synaptic genes (DAT, DRD2, MAPT, PSD95) in blood and CSF of schizophrenia (SZ) patients and healthy controls (Co).
- DAT methylation was significantly higher in the blood of Co compared to SZ patients' blood and CSF.
- PSD95 methylation was higher in CSF than blood of SZ patients, with no difference in blood between SZ and Co.
- No significant differences in MAPT and DRD2 methylation rates between groups.
- Low sequencing success in Co CSF suggests higher DNA fragmentation compared to SZ.
- Higher PSD95 methylation in SZ may support the glutamate hypothesis of schizophrenia.
- Lower DAT methylation in SZ could indicate higher dopamine transporter availability, possibly compensating for dopaminergic hyperactivity.