Gut microbiome signatures in colorectal neoplasia: a cross-sectional study across neoplasia stages and subtypes - PubMed
5 days ago
- #colorectal neoplasia
- #metagenomics
- #gut microbiome
- The study investigates gut microbiome signatures in colorectal neoplasia across different stages and subtypes.
- Findings show minimal differences in gut microbiome composition between individuals with and without neoplasia.
- Specific species and microbial pathways were modestly linked to neoplasia, particularly early lesions.
- Predictive models combining microbiome data with clinical/demographic features slightly improved high-risk neoplasia classification.
- The study concludes weak and inconsistent associations between the gut microbiome and premalignant colorectal neoplasia.
- Longitudinal, multiomic studies are suggested to better understand the temporal and causal pathways.