Silk fibroin hydrogel adhesive combined with miR-455 modified framework nucleic acids/ROS-responsive CeO2 nanozymes for meniscus tears reconstruction - PubMed
5 hours ago
- #nanozymes
- #hydrogel adhesive
- #meniscus repair
- Meniscus tears have poor self-healing potential, leading to osteoarthritis.
- Current treatments like surgical suturing or partial resection have limited efficacy.
- A multifunctional composite hydrogel system was developed for meniscus repair.
- The system includes methacrylated silk fibroin (SilMA), CeO2 nanozymes, and tFNA-miRNA-455.
- SilMA hydrogel offers injectability, strong tissue adhesion, and mechanical support.
- CeO2 nanozymes scavenge ROS, reducing inflammation and promoting regeneration.
- tFNAs deliver miRNA-455 efficiently, promoting chondrogenic differentiation of SMSCs.
- The strategy combines structural reinforcement, immunomodulation, and stem cell regulation.
- This approach shows promise for cartilage regeneration and meniscus function restoration.