The three-dimensional perspective of CAR-T cell therapy in autoimmune diseases - PubMed
5 hours ago
- #Immune remodelling
- #CAR-T therapy
- #Autoimmune diseases
- CAR-T cell therapy is originally successful in hematological malignancies and is now being explored for autoimmune diseases (AIDs) to achieve deep immune remodelling and durable drug-free remission.
- The review assesses CAR-T therapy in AIDs using a three-dimensional framework: depth (therapeutic efficacy and immune remodelling mechanisms), breadth (disease spectra and target selection), and length (long-term persistence and safety).
- The goal of this framework is to support more precise and controllable clinical development of CAR-T cell therapy for autoimmune diseases.