Bioinformatics Profiling of a Paeoniflorin-Associated "Macrophage-Lactylation" Axis in Hepatocellular Carcinoma: An LDHA-Based Prognostic Model and Structural Computational Evidence - PubMed
6 hours ago
- #lactylation
- #prognostic model
- #hepatocellular carcinoma
- Study focuses on macrophage-lactylation molecular axis in hepatocellular carcinoma (HCC).
- A prognostic model was developed using genes HNRNPU, LDHA, and NPM1.
- High-risk patients showed poorer overall survival (p < 0.001).
- Molecular docking indicated strong binding of Paeoniflorin (PF) to LDHA.
- Proposed model links PF to key molecular nodes like LDHA with computational evidence.