Global burden, temporal trends and cross-national inequalities of the comorbidity between depressive disorder and hormone-dependent tumors in women of reproductive ages from 1990 to 2021: A population
7 hours ago
- #depressive-disorder
- #women-health
- #hormone-dependent-tumors
- Analyzed global comorbidity burden of depressive disorder (DD) and hormone-dependent tumors (HDTs) in women of reproductive ages (WRAs) from 1990 to 2021.
- Used Global Burden of Disease (GBD) 2021 data to study incidence, prevalence, and disability-adjusted life years (DALYs).
- Applied Joinpoint regression for trends, Bayesian age-period-cohort (BAPC) model for projections to 2036, and APC model for temporal trends.
- Found increasing age-standardized incidence rate (ASIR) and prevalence rate (ASPR), but decreasing age-standardized DALYs rate (ASDALYsR).
- Identified women aged 45-49 years as the highest-risk group.
- Population growth and epidemiological changes were main drivers of increasing burden.
- High-SDI countries had greater comorbidity burden, but gap with low-SDI regions is narrowing.
- High-SDI regions have the largest potential for burden reduction.
- Projected rising comorbidity burden over next 15 years; recommends integrating depression screening into oncologic care.