Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models - PubMed
3 hours ago
- #mitochondrial transplantation
- #Parkinson's disease
- #organelle therapy
- Mitochondrial transplantation shows potential for treating mitochondrial diseases.
- A new approach delivers mitochondria efficiently using vesicles from erythrocyte plasma membranes.
- Encapsulated mitochondria rescued bioenergetic and biochemical defects in patient-derived cells.
- Mitochondrial capsules alleviated mitochondrial DNA depletion syndrome and Leigh syndrome in mouse models.
- In a Parkinson's disease mouse model, mitochondrial capsules improved neuron survival and motor skills.
- The study proposes 'organelle therapy' as a strategy in regenerative medicine.