Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration - PubMed
6 hours ago
- #bone marrow mesenchymal stromal cells
- #alcohol-associated liver disease
- #IL-1R2 monocytes
- BM-MSCs release glutamate via xCT (Slc7a11) in response to alcohol exposure.
- Glutamate activates mGluR5 on NK cells, leading to IFN-γ production.
- IFN-γ promotes IL-1R2 expression and reduces CX3CR1 in Ly6Clow monocytes.
- IL-1R2+ monocytes migrate to the liver, mitigating alcohol-associated liver disease.
- Knockout of xCT in MSCs or mGluR5 in NK cells worsens liver injury in mice.
- Increased IL-1R2 is found in ALD patients, and recombinant IL-1R2 improves ALD in mice.