Locus coeruleus-hippocampus noradrenergic activation alleviates sepsis-associated encephalopathy by promoting astrocytic AQP4-related autophagy via α2A-AR - PubMed
6 hours ago
- #Sepsis-associated encephalopathy
- #Hippocampus
- #Astrocyte
- LC-HP-NA activation alleviates sepsis-associated encephalopathy (SAE) by promoting astrocytic AQP4-related autophagy via α2A-AR.
- Sepsis impairs the LC-HP-NA system and long-term neurocognition, increasing hippocampal astrocytic AQP4 expression and inhibiting autophagy.
- LC-HP-NA activation elevates hippocampal noradrenaline release, promotes astrocytic autophagy, suppresses astrocyte reactivity, and improves cognitive function.
- Knockdown of hippocampal astrocytic α2A-AR or overexpression of AQP4 eliminates the neuroprotective effects of LC-HP-NA activation.
- α2A-AR activation reduces AQP4 expression and enhances PPAR-γ/mTOR-dependent autophagy via the cAMP/PKA signaling pathway.