Unveiling the multifaceted roles of BCL3: biological functions and disease implications - PubMed
3 hours ago
- #BCL3
- #Oncogene
- #NF-κB signaling
- BCL3 is an atypical member of the IκB protein family, primarily localized in the nucleus.
- It has bidirectional transcriptional regulatory functions within the NF-κB signaling pathway, modulated by post-translational modifications like phosphorylation.
- BCL3 acts as an oncogene in pathological conditions, promoting cell proliferation, inhibiting apoptosis, and enhancing metastasis and chemotherapy resistance.
- It plays a critical role in immune homeostasis by modulating macrophages, T cells, and dendritic cells, influencing immune-related disorders.
- BCL3 is involved in various systems including nervous, cardiovascular, digestive, and musculoskeletal, indicating broad physiological and pathological significance.
- The article reviews BCL3's molecular structure, regulatory mechanisms, and roles in neoplastic and non-neoplastic diseases, suggesting diagnostic and therapeutic potential.