Association of baseline immune cell composition with CAR-T cell expansion and survival in Relapsed/Refractory large B-Cell lymphoma - PubMed
5 hours ago
- #biomarker research
- #CAR-T therapy
- #immune profiling
- Baseline immune cell composition correlates with CAR-T expansion patterns in R/R LBCL patients, with higher naive T cells, helper T cells, and CD4/CD8 ratio linked to better expansion.
- Patients with high CAR-T expansion had improved PFS, and a higher baseline CD4/CD8 ratio was associated with longer progression-free survival (HR 0.41, p=0.047).
- Exploratory analysis suggested PD-1 inhibitor maintenance therapy may influence the association between baseline PD-1 expression and PFS, but findings are preliminary and require validation.
- The study, involving 33 patients treated with CD19/CD22 bispecific CAR-T therapy, is hypothesis-generating due to small sample size and retrospective design.
- Baseline PD-1 expression is not yet supported as a predictive biomarker, and larger prospective studies are needed to confirm these immune profiling associations.