Macrophages expressing macrophage receptor with collagen structure attenuate liver fibrosis through a tissue restoration phenotype - PubMed
6 hours ago
- #Liver Fibrosis
- #MARCO
- #Macrophages
- Macrophages expressing MARCO (macrophage receptor with collagen structure) play a key role in attenuating liver fibrosis.
- Single-cell RNA-seq in a mouse model revealed increased macrophage diversity during liver injury, with Marco being significantly upregulated.
- MARCO+ macrophages exhibited a restorative phenotype, reducing proinflammatory gene expression and enhancing phagocytosis.
- Adoptive transfer of MARCO+ macrophages in a liver fibrosis model reduced ECM-associated gene expression in hepatic stellate cells (HSCs) and collagen deposition.
- MARCO+ macrophages interact with HSCs to attenuate fibrogenesis, suggesting a potential therapeutic pathway for liver fibrosis.