Lycium barbarum Polysaccharides-enriched extract Ameliorate Rheumatoid Arthritis via Gut microbiota-mediated regulation of the Tfh/B cell axis - PubMed
6 hours ago
- #Gut Microbiota
- #Rheumatoid Arthritis
- #Immunoregulation
- Gut microbiota dysbiosis is linked to rheumatoid arthritis (RA).
- Lycium barbarum polysaccharide-enriched extract (LBP) has anti-inflammatory and immunoregulatory effects.
- RA patients and CIA rats showed reduced gut microbiota α-diversity and altered bacterial levels (e.g., decreased Ligilactobacillus, increased Blautia).
- LBP treatment in CIA rats reversed microbiota shifts, increasing beneficial bacteria and reducing harmful ones.
- LBP reduced splenic Tfh and B cell proportions, lowered inflammatory markers (IgG, IL-6, IL-21), and improved joint and colon tissue health.
- Dysbiosis and Tfh cell overactivation are key in RA progression.
- LBP may suppress Tfh cell proliferation and abnormal B cell differentiation, potentially via gut microbiota regulation.