IL-15 Links Muscle-Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy - PubMed
5 hours ago
- #IL-15
- #mitochondrial fusion
- #diabetic nephropathy
- IL-15 mediates muscle-kidney crosstalk to protect podocytes in diabetic nephropathy (DN).
- Overexpression of PGC-1α in skeletal muscle (mPGC-1α) reduces kidney damage in diabetic mice.
- mPGC-1α:db/db mice show improved kidney function, including reduced albumin excretion and preserved podocyte number.
- IL-15 treatment enhances podocyte mitochondrial respiration and preserves mitochondrial fusion under high glucose.
- IL-15 promotes OPA1 expression via histone H3 acetylation, maintaining mitochondrial function in podocytes.
- Targeting the IL-15 pathway may offer a therapeutic strategy to slow DN progression.