A Short Review and Update on Epidemiology, Treatment, and Management of Herpes Zoster (Shingles) Infection - PubMed
4 hours ago
- #Antiviral Treatment
- #Herpes Zoster
- #Postherpetic Neuralgia
- Herpes zoster (shingles) is caused by the reactivation of the Varicella-Zoster Virus (VZV) after initial infection.
- The virus remains dormant in nerve ganglia and, upon reactivation, causes painful rash, blisters, and inflammation.
- Complications include Postherpetic Neuralgia (PHN), vision loss, neurological issues, and secondary infections.
- HZ has a 20-30% lifetime risk, increasing with age, especially in the elderly and immunocompromised.
- Treatment involves antivirals like acyclovir, famciclovir, valacyclovir, amenamevir, and brivudine to combat viral replication.
- Vaccination significantly reduces HZ and PHN incidence in individuals over 60.
- New antivirals targeting Herpesviridae species are under research for future treatment options.
- Management focuses on reducing PHN, Zoster-Associated Pain (ZAP), and promoting recovery.