Tubulin Acetylation Deficiency Promotes Axonemal Turnover and Increases Cytoplasmic Microtubules - PubMed
5 hours ago
- #cilia regeneration
- #microtubule dynamics
- #tubulin acetylation
- Tubulin acetylation deficiency was studied using a Chlamydomonas mutant lacking αTAT1 acetyltransferase.
- Loss of acetylation increased axonemal tubulin turnover but did not affect steady-state lengths of axonemes and rootlets.
- The mutant showed an increased number of dynamic cortical microtubules and could regenerate cilia without protein synthesis.
- Increased cortical microtubules depended on the presence of cilia, as shown by an ift46-1 mutation abolishing ciliogenesis.
- Cell growth and division remained normal despite cytoskeletal changes, suggesting cellular buffering against microtubule variations.