The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis - PubMed
5 hours ago
- #immunotherapy
- #NLRP3 immunosome
- #colorectal cancer
- Aberrant activation of NLRP3 in microsatellite stability (MSS) colon cancer is linked to lymph node metastasis.
- NLRP3 activation promotes M2 macrophage polarization, affecting CD8+ T lymphocyte infiltration and creating a suppressive immune microenvironment.
- Study utilizes TCGA-COAD data and tissue microarray analysis from 100 colorectal cancer (CRC) patients and 60 adjacent noncancerous tissues.
- Findings highlight the role of NLRP3 immunosome in regulating the tumor immune microenvironment in MSS-CRC patients.
- Research underscores the potential of targeting NLRP3 for immunotherapy in colorectal cancer.