PARTIAL: study protocol for a clinical and cost-effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma randomised trial - PubMed
4 hours ago
- #Kidney cancer
- #Renal cell carcinoma
- #Nephron-sparing surgery
- The PARTIAL trial is a randomized controlled study comparing partial nephrectomy (PN) and radical nephrectomy (RN) for clinically localized renal cell carcinoma (RCC).
- The study aims to determine if PN, which preserves renal function, is superior to RN in complex T1 tumors (T1b or endophytic T1a) with a normal contralateral kidney.
- Primary outcomes include renal function preservation at 2 years and surgical complications during the peri-operative period.
- Secondary outcomes cover quality of life, cost-effectiveness, surgical margins, recurrence rates, cardiovascular events, and overall survival.
- The trial will recruit 420 participants in UK NHS centers, excluding those with metastatic disease, chronic kidney disease, or other specific conditions.
- Results may influence clinical practice, potentially favoring RN if PN does not show significant benefits or has excess complications.