Sugar-sweetened beverage consumption and incident depression: an exploratory multi-omics analysis of candidate biological mediators - PubMed
4 hours ago
- #depression
- #multi-omics
- #sugar-sweetened beverages
- High sugar-sweetened beverage (SSB) consumption is associated with an 18% increased risk of incident depression compared to non-consumers.
- A proteomic signature of 229 plasma proteins was linked to a higher depression risk, with 72 proteins, 36 metabolites, and 5 inflammatory markers identified as candidate mediators.
- The strongest mediating effects were observed for protein IL1RN (9.6%), metabolite unsaturation, and inflammatory marker neutrophil count.
- Findings are exploratory and require future experimental validation to confirm biological pathways and potential intervention targets.