Bacteriophage Therapy: Current Strategies and Future Perspectives - PubMed
12 hours ago
- #vaccine-development
- #phage-therapy
- #antimicrobial-resistance
- Antimicrobial resistance is a significant global health threat requiring alternative treatments.
- Phage therapy resurges as a promising solution for multidrug-resistant infections.
- Applications include treating infections, preventing hospital-acquired infections, and developing vaccines.
- Advanced strategies: phage-antibiotic synergy, biomaterial-enhanced delivery, and engineered phages.
- Genetic engineering broadens phage host ranges and converts temperate phages into lytic variants.
- Phages prevent hospital infections by eliminating biofilms and disinfecting surfaces.
- Phages serve as a versatile platform for vaccine development.
- Challenges include pharmacokinetics, standardized production, and regulatory approval.
- Recent preclinical and clinical developments highlight transformative potential despite barriers.