NETosis-derived PADs mediate Citrullination of Oral Bacteria to promote Inflammation in Rheumatoid Arthritis - PubMed
5 hours ago
- #NETosis
- #Rheumatoid Arthritis
- #Periodontal Disease
- Periodontal disease (PD) is a known risk factor for rheumatoid arthritis (RA).
- Oral bacteria induce NETosis in neutrophils, leading to PAD4 activation and citrullination of bacterial and neutrophil proteins.
- Citrullinated oral bacteria trigger TLR9-Syk-mediated B cell activation, proliferation, and ACPA production.
- ACPA-bound citrullinated bacteria form immune complexes that activate proinflammatory macrophages (secreting TNFα and IL-6) and inhibit anti-inflammatory macrophages.
- Citrullinated oral bacteria from PD may enter circulation, promoting synovial inflammation and joint destruction in RA.