Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia - PubMed
5 hours ago
- #CAR T-cell therapy
- #CD7-targeted
- #acute myeloid leukemia
- Autologous second-generation CD7-directed CAR T-cells were developed to target CD7+ acute myeloid leukemia.
- An anti-CD7 protein expression blocker was used to prevent self-killing fratricide in the CAR T-cells.
- Three pediatric/young adult patients with relapsed/refractory CD7+ AML were treated, achieving measurable residual disease negativity.
- The treatment demonstrated a favorable safety profile.