Autoantibodies as predictors of progression to rheumatoid arthritis: a systematic review and meta-analysis - PubMed
3 months ago
- #Meta-Analysis
- #Rheumatoid Arthritis
- #Autoantibodies
- Autoantibodies increase the risk of developing rheumatoid arthritis (RA) by 3.1 to 19.3 times compared to autoantibody-negative individuals.
- The highest cumulative incidence of RA at 12 months (35.2%) was observed in CCP2-positive individuals with arthralgia and IgM-RF.
- Individuals with arthralgia are at the highest risk of progressing to RA within the first 24 months of follow-up.
- The study analyzed 26 eligible articles out of 293 screened, focusing on autoantibodies as predictors of RA.
- Various autoantibodies were examined, with CCP2 and IgM-RF in combination with arthralgia showing the fastest progression to RA.