Predictors of Long-Term Outcomes in Hypertrophic Cardiomyopathy: The NHLBI HCM Registry - PubMed
4 hours ago
- #risk prediction
- #hypertrophic cardiomyopathy
- #cardiac magnetic resonance
- Current risk prediction guidelines for hypertrophic cardiomyopathy predict only sudden cardiac death and are imperfect, leading to avoidable deaths and unnecessary implantable cardioverter defibrillators.
- A registry-based study of 2750 patients from North America and Europe combined clinical history, imaging, genetic, and biomarker data to improve risk prediction for adverse events.
- Key predictors for the primary composite endpoint (HCM-related deaths, nonfatal ventricular arrhythmias, LV assist device or heart transplant) included LV scar percentage, LV mass index, LV end-systolic volume index, history of heart failure, and log(NT-proBNP).
- An LV scar percentage of 9% or higher significantly increased the primary composite event rate.
- Predictors for the secondary endpoint (sudden cardiac death and nonfatal ventricular arrhythmias) included LV scar percentage, LV mass index, LV ejection fraction, and log(NT-proBNP).
- The study provides prospective evidence supporting the incorporation of cardiac magnetic resonance and NT-proBNP in evaluating patients with hypertrophic cardiomyopathy.