TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition - PubMed
2 days ago
- #Pulmonary Fibrosis
- #TRPML1
- #Extracellular Matrix
- TRPML1 suppresses pulmonary fibrosis by regulating MMP levels in the extracellular matrix (ECM).
- Loss of TRPML1 leads to excessive accumulation of collagen and elastin, contributing to lung fibrosis.
- TRPML1 activation increases MMP levels, which are crucial for collagen and elastin degradation.
- Mucolipidosis type IV (MLIV) mice exhibit a fibrosis-like lung phenotype similar to bleomycin-induced fibrosis.
- The study identifies TRPML1 as a key regulator of MMP release in the lung.