Coupling of cargo to the autophagy receptor is a critical step in ER-phagy - PubMed
5 hours ago
- #lipid regulation
- #ER-phagy
- #autophagy receptors
- During ER-phagy (endoplasmic reticulum autophagy), receptors like Atg40 remodel the ER by capturing membrane proteins (cargo) into autophagosomes for degradation during cell stress.
- Atg40 requires Lst1/SEC24C for cargo capture, but in neutral lipid-deficient cells, it can be delivered to the vacuole without Lst1/SEC24C or cargo.
- Lipidomic analysis shows changes in phosphatidylethanolamine to phosphatidylcholine ratios in these cells, suggesting phospholipids regulate cargo sequestration by affecting membrane bendability and receptor-cargo coupling.