Identification of vital sign trajectory phenotypes and treatment response heterogeneity in critically ill patients with ischemic stroke: A multicenter study with external validation - PubMed
5 hours ago
- #Ischemic Stroke
- #Trajectory Phenotyping
- #Critical Care
- Identified three distinct vital sign trajectory phenotypes in critically ill ischemic stroke patients using group-based multi-trajectory modeling: tachycardic-tachypneic, hypertensive-stable, and low-diastolic quiescent.
- Phenotypes showed significant differences in mortality rates, with tachycardic-tachypneic having the highest risk, and phenotype-based classification outperformed traditional severity scores in predicting one-year mortality.
- Exploratory analysis revealed phenotype-specific treatment responses, including differential dose-mortality associations for normal saline and propofol, suggesting potential for precision-guided therapies.