Antenatal N-acetylcysteine supplementation in pregnant women with impending preterm birth: a prospective randomized placebo-controlled trial - PubMed
4 hours ago
- #Glutathione
- #Preterm Birth
- #N-acetylcysteine
- The study investigated antenatal N-acetylcysteine (NAC) supplementation in pregnant women at risk of preterm birth, finding it did not restore glutathione (GSH) levels but was safe.
- NAC was associated with prolonged pregnancy duration (44.5 vs. 36 days) and a higher percentage of infants free of neonatal complications (85% vs. 52.6%).
- The trial observed changes in sulfur and nitric-oxide pathways in maternal and neonatal blood metabolomic signatures, suggesting potential metabolic impacts.
- As a pilot study, the results indicate a need for larger trials to confirm trends in pregnancy prolongation and reduced neonatal morbidity.