Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies - PubMed
5 hours ago
- #meta-analysis
- #suicide-prevention
- #psychotropic-medications
- Psychiatric disorders increase suicide risk, and the impact of psychotropic medications on these outcomes is uncertain.
- Systematic review and meta-analysis of observational studies involving over 6 million people from 13 countries.
- Second-generation antipsychotics like clozapine, olanzapine, quetiapine, and zuclopenthixol reduce suicide mortality in schizophrenia spectrum disorders.
- Lithium and valproic acid lower suicide risks in bipolar disorder; SSRIs and tricyclic antidepressants reduce suicide mortality in depression.
- Benzodiazepines are associated with higher suicide mortality in most diagnostic categories, except depression.
- Evidence suggests varying effects of psychotropic medications on suicide-related outcomes across different psychiatric disorders.
- Observational study limitations include residual confounding, high heterogeneity, and moderate evidence quality.