Machine learning-guided Huanglian Jiedu decoction targets STING in periodontitis-induced Alzheimer's Disease - PubMed
5 hours ago
- #Alzheimer's Disease
- #Machine Learning
- #Neuroinflammation
- Alzheimer's disease (AD) is linked to chronic periodontitis (CP), but the molecular mechanisms are unclear.
- Huanglian Jiedu Decoction (HLJDD) was studied for its effects on CP-induced AD using machine learning and multi-omics.
- Single-cell RNA-sequencing showed inflammatory activation in microglia from AD samples.
- A CP-induced AD rat model was created, and hippocampal transcriptomic profiling was performed.
- Machine learning strategies identified the cGAS-STING pathway as central to CP-AD pathology.
- HLJDD suppressed cGAS-STING activation, reduced neuroinflammation, and improved cognitive function in CP-induced AD models.
- The study highlights machine learning's role in mechanistic prioritization and HLJDD as a potential therapy for CP-induced AD.