A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation - PubMed
3 months ago
- #neuroscience
- #music_therapy
- #pain_management
- The study explores a neural circuit between the primary auditory cortex (Au1) and anterior cingulate cortex (ACC) involved in cross-modal visceral pain modulation.
- Early-life stress suppresses Au1 inhibitory (GABAergic) neurons, leading to disinhibition of ACC excitatory (glutamatergic) neurons, which drives visceral hypersensitivity.
- Music intervention alleviates visceral pain by restoring Au1GABA neuronal activity and suppressing ACCGlu activity.
- The findings provide a mechanistic basis for the clinical use of music therapy in managing visceral pain.
- The study highlights the potential of non-pharmacological interventions like music for treating stress-induced visceral pain.