VPS13C-mediated endoplasmic reticulum-lysosome tethering in neuronal stress responses - PubMed
5 hours ago
- #Organelle Tethering
- #Parkinson's Disease
- #Neuronal Stress Response
- VPS13C facilitates tethering between the endoplasmic reticulum (ER) and lysosomes, crucial for neuronal stress responses and cellular homeostasis.
- It acts as a lipid transport channel, supporting membrane repair by transferring lipids from the ER to damaged lysosomal membranes.
- ER-lysosome contacts may integrate with ER-mitochondria junctions to form signaling hubs that coordinate lipid redistribution, calcium signaling, and mitochondrial adaptation.
- These interactions can activate transcription factors like TFEB and TFE3, regulating lysosomal biogenesis and autophagy.
- Disruption of VPS13C function is linked to Parkinson's disease, affecting lysosomal homeostasis and pathways involving α-synuclein, mitophagy, and LRRK2 signaling.