A multifaceted interplay between hemophagocytosis, IL-18 and type I IFN distinguishes Still disease from other autoinflammatory diseases - PubMed
5 hours ago
- #Still disease
- #omics
- #autoinflammatory diseases
- Still disease (SD) is distinguished from other systemic autoinflammatory diseases (SAID) by a unique interplay between hemophagocytosis, IL-18, and type I IFN signaling.
- Key findings include elevated plasma heme oxygenase 1 (HO-1) and IL-18 in SD, which correlate strongly but are not linked to general inflammation.
- SD is characterized by ferroptosis in plasma, type I IFN signaling in monocytes, and elevated NK cell miRNA-146a-5p, an IL-18 induced miRNA.
- The study identified two distinct subgroups of SD patients, differentiated by the degree of hemophagocytic activity rather than disease activity or inflammation.
- This research provides a large omics dataset (proteomics and RNAseq) that serves as a valuable resource for further investigation into SD and other SAIDs.