Low-Intensity Pulsed Ultrasound Promotes Spinal Cord Injury Recovery by Regulating Microglia-Mediated Neuroinflammation - PubMed
5 hours ago
- #spinal cord injury
- #neuroinflammation
- #low-intensity pulsed ultrasound
- Low-Intensity Pulsed Ultrasound (LIPUS) promotes recovery in spinal cord injury (SCI) by regulating microglia-mediated neuroinflammation.
- LIPUS intervention in rats reduced spinal cord cavity area, inhibited microglial activation, promoted M2-type polarization, and improved hindlimb motor function.
- In vitro studies showed LIPUS enhanced BV2 microglial cell viability, upregulated anti-inflammatory factors, and downregulated pro-inflammatory factors, reducing neuron apoptosis.
- RNA sequencing identified differentially expressed genes through immune defense and signaling pathways, with downregulation of hub genes like CXCR2 contributing to anti-inflammatory effects.
- The study provides a basis for clinical application of LIPUS in SCI and supports combining it with other therapies for multimodal treatment approaches.