Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression - PubMed
5 hours ago
- #Nitrate Respiration
- #Microbiota
- #Chronic Kidney Disease
- Chronic kidney disease (CKD) is associated with increased fecal abundance of Enterobacteriaceae.
- The uremic toxin indoxyl sulfate, derived from microbiota-produced indole, worsens CKD progression.
- In adenine-induced CKD mice, impaired indoxyl sulfate clearance increases iNOS expression, raising luminal nitrate levels.
- Elevated nitrate levels promote Escherichia coli growth via nitrate respiration.
- CKD patient fecal microbiota produces more indole than healthy controls under anaerobic conditions with nitrate.
- Nitrate enhances E. coli indole production, exacerbating renal pathology in CKD mice.
- iNOS inhibition mitigates the negative effects of nitrate-driven indole production.