A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis - PubMed
6 hours ago
- #glycan vaccine
- #Streptococcus suis
- #zoonotic pathogen
- Streptococcus suis is an emerging bacterial zoonotic pathogen with global implications for animal welfare, antibiotic resistance, and human health.
- No effective vaccines are currently available for Streptococcus suis.
- Researchers identified two cell wall polysaccharide variants in pathogenic S. suis strains that differ due to allelic variation in a glycosyltransferase gene.
- Deletion of the variable glycosyltransferase revealed a conserved glycan core affecting morphology and lysozyme resistance.
- Immunization of pigs with this core glycan elicited antibodies that recognized diverse pathogenic strains and induced complement deposition.
- These findings offer insights for developing next-generation glycoconjugate vaccines targeting a single glycan to protect against S. suis.
- Some authors are employed by MSD Animal Health, where a vaccine based on another antigen is under development.