Retatrutide And Lipid And Metabolite Profiles In Participants With Obesity With Or Without Type 2 Diabetes - PubMed
3 hours ago
- #metabolomics
- #obesity
- #retatrutide
- Retatrutide was assessed for its effects on plasma metabolome and lipidome in two phase 2 trials involving participants with obesity, with and without type 2 diabetes (T2D).
- Higher doses of retatrutide led to changes in metabolites like 3-hydroxybutyrate and acylcarnitines, which mediated 23.2% of weight reduction in non-T2D participants and 12.7% in T2D participants.
- Treatment also altered metabolites related to insulin resistance, including branched-chain amino acids and triglycerides, with sustained improvements across study endpoints.
- The findings suggest retatrutide enhances fatty acid oxidation and reduces insulin resistance, potentially lowering cardiovascular risk and improving metabolic health.