Reduced FBXO22 skews human trophoblast fate equilibrium toward syncytialization via polyubiquitinating the CoREST complex - PubMed
3 hours ago
- #ubiquitination
- #FBXO22
- #trophoblast differentiation
- FBXO22, part of an SCF E3 ubiquitin ligase complex, regulates trophoblast fate by maintaining a balance between self-renewal and differentiation into syncytiotrophoblasts (STBs).
- Reduced FBXO22 levels are linked to recurrent pregnancy loss (RPL) and cause premature STB differentiation by destabilizing the CoREST complex, affecting histone modifications like H3K27ac and H3K9me2.
- The study reveals a nuclear ubiquitination pathway where FBXO22 polyubiquitinates the CoREST complex, coordinating with HDAC1 and LSD1 to control trophoblast homeostasis and placental development.