Integrated Genomic and Transcriptomic Analysis Reveals the Genetic Basis and Causal Association Between Obesity and Atrial Fibrillation - PubMed
4 hours ago
- #genetic-basis
- #pleiotropic-genes
- #obesity-atrial-fibrillation
- The study integrated genomic and transcriptomic analyses to explore the genetic basis and causal association between obesity and atrial fibrillation (AF).
- A significant genetic correlation was found between obesity and AF, with obesity having a positive causal effect on AF, but no reverse causality.
- Key pleiotropic genes identified include NFATC2IP, NUCKS1, and PCCB, which show tissue-specific expression in adipose and cardiac tissues and are linked to increased risks of both obesity and AF.
- The findings suggest new genetic insights and potential therapeutic targets for obesity-related AF, supporting a unidirectional causal relationship from obesity to AF.