NimA promotes cell adhesion at the blood brain barrier of the Drosophila nervous system - PubMed
4 hours ago
- #Neurodevelopment
- #Drosophila
- #Glia
- NimA is a glial-specific protein in Drosophila, part of the Nimrod family, but unlike other members, it is not involved in phagocytosis.
- NimA regulates cell-cell adhesion, essential for maintaining tight septate junctions at the larval blood-brain barrier (BBB).
- Loss of NimA in BBB-forming glia compromises barrier integrity and delays development, reduces brain size, impairs proliferation, and decreases the neural stem cell pool.
- The study highlights the importance of glial-specific molecular players like NimA in understanding nervous system function and development.