Migraine and the Gut-Brain Axis-The Role of Microbiome-Targeted Biotics - PubMed
5 hours ago
- #probiotics
- #migraine
- #gut-brain-axis
- Migraine is a prevalent and disabling headache disorder often accompanied by gastrointestinal symptoms.
- Alterations in gut microbiota and the microbiome-gut-brain axis may contribute to migraine pathophysiology.
- Potential mechanisms include immune activation, oxidative stress, impaired intestinal barrier function, and neuroinflammatory signaling.
- Probiotics, prebiotics, and postbiotics show promise in modulating migraine through inflammatory cytokine profiles, enhancing gut barrier integrity, and reducing oxidative stress.
- Clinical trials suggest benefits of probiotics (e.g., Lactobacillus and Bifidobacterium strains) in reducing migraine frequency, severity, and analgesic use.
- Prebiotics (e.g., inulin-type fructans) and microbiota-derived metabolites like short-chain fatty acids also show potential, though clinical data is limited.
- Current evidence lacks standardization; more well-powered, placebo-controlled trials are needed to define optimal interventions and responders.