New insights in multiple sclerosis pathology - PubMed
5 hours ago
- #neuropathology
- #neuroinflammation
- #neurodegeneration
- Relapse-associated worsening and progression independent of relapse activity both contribute to long-term disability in multiple sclerosis (MS).
- Tissue resident memory cells and microglia are key drivers of persistent CNS inflammation and disease progression.
- Soluble factors, including interferon γ, play a detrimental role in neuronal injury, synapse damage, and impaired remyelination.
- Modern -omics approaches (e.g., snRNA sequencing, spatial transcriptomics) have advanced understanding of immune-neural interactions in MS.
- Insights from human tissue studies may lead to novel therapies targeting CNS inflammation, neurodegeneration, and promoting remyelination.