Interaction of genetic and lifestyle risk scores on colorectal cancer risk across five racial and ethnic populations - PubMed
4 days ago
- #lifestyle factors
- #genetic risk
- #colorectal cancer
- Study investigates the interaction of genetic and lifestyle risk scores on colorectal cancer (CRC) risk across five racial and ethnic populations.
- Genetic predisposition assessed using a 205-variant polygenic risk score (PRS), lifestyle risk score based on smoking, alcohol, BMI, physical activity, and diet.
- Highest PRS quintile associated with a 2.4-fold increase in CRC risk compared to the lowest quintile.
- Highest lifestyle risk score quintile linked to a 54% increased CRC risk, stronger in those with high genetic risk.
- Lifestyle modification may offer greater risk reduction for individuals with higher genetic risk.
- Results consistent across African American, Japanese American, Latino, Native Hawaiian, and White populations.