Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - PubMed
14 hours ago
- #arthritis
- #interferon signaling
- #pain
- Persistent interferon signaling leads to sensory neuron plasticity and pain before and during arthritis.
- Early immune activation and cytokine storm in arthritis are driven by vascular cells and monocytes/macrophages in the dorsal root ganglion.
- MNK1/MNK2-eIF4E signaling pathway activation causes sensory-motor dysfunction and pain by hyperexcitability and sensitization of GFRA3+ C-fiber sensory neurons.
- Inhibition of the signaling pathway in vivo reverses pain and restores limb function.
- Human sensory neurons express interferon receptors, with increased type 1 interferons and signaling observed in painful rheumatoid arthritis patients.
- The study suggests potential for targeted therapies for pain relief in arthritis.