B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response - PubMed
5 hours ago
- #splenic marginal zone
- #CD8+ T-cell response
- #B cells
- B cells are essential for maintaining the homeostasis of splenic marginal zone antigen-presenting cells.
- B-cell-deficient mice show weaker primary virus-specific CD8+ T-cell responses and increased viral transcription.
- B cells sustain Langerin+ type 1 conventional dendritic cells (cDC1s) in the splenic marginal zone, crucial for viral clearance.
- The presence of Langerin+ cDC1s depends on B cells expressing lymphotoxin (LTβ) to maintain CD169+ marginal metallophilic macrophages (MMMs).
- Communication between MMMs and Langerin+ cDC1s is mediated via the VCAM1-ITGA4/ITGB1 interaction.
- B cells regulate MMM development via LTβ expression, sustaining Langerin+ cDC1 homeostasis for effective antiviral CD8+ T-cell responses.
- The study provides insights into B cell roles in immune responses, applicable to infectious diseases, autoimmune conditions, and tumors.