Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - PubMed
4 hours ago
- #fertility
- #gut microbiota
- #ovarian aging
- Ovarian function decline with age affects fertility and increases risk of age-related diseases like osteoporosis and dementia.
- Earlier menopause is linked to shorter lifespan, but mechanisms of ovarian aging are not well understood.
- Gut microbiota may influence ovarian health, as shown in female mice studies.
- Fecal microbiota transplantation from young or estropausal mice improves ovarian transcriptome and reduces inflammation-related gene expression.
- Molecular changes from microbiota transfer lead to enhanced ovarian health and increased fertility.
- Metagenomics and metabolomics identify microbial species and metabolites that may contribute to ovarian rejuvenation.
- Findings reveal a direct link between gut microbiota and ovarian health.